COVID-19 Drugs: Materials for Clinical Research, Drug Development and TDM

Researchers are working furiously to test a variety of potential drugs to find a suitable treatment for COVID-19, the disease caused by SARS-CoV-2. To support laboratories with this challenge, Chromsystems offers calibrator and control material of drug candidates, aimed at supporting your clinical research. We as assay manufacturer are aware of our duty to quickly supply material of highest quality. We ensure that the 3PLUS1® calibrator and MassCheck® controls are produced with a maximum of quality to support your efforts in the best possible way. 

 

Drugs	3PLUS1 Calibrator Approximate range of level 1-3 [μg/l]**	QC Material          Approximate range                 [μg/l]**
GS 5734/Remdesivir	85-2700	730 - 2130
GS 441524  (active metabolite of Remdesivir)	22-95	35 - 67
Lopinavir	390-6300	1070 - 4970
Ritonavir	95-6250	770 - 4940
Favipiravir	3291-10400	2680 - 7980
Chloroquine	18-450	110 - 350
Hydroxychloroquine	460-1150	470 - 940
Nafamostat	2-200	45 - 170
Azithromycin	40-440	150 - 350

 

We also developed a test protocol to ensure that all analytes can be measured reliably with MassTox® TDM Series A*, our modular solution for the  therapeutic drug monitoring (TDM) of more than 200 drugs. Existing users can simply use the same chromatographic set up, sample prep and MasterColumn®. All you need are a few additional components from MassTox® TDM Series A as described in the application note here.

 

 

The chromatographic setup of MassTox® TDM Series A can be used to determine these drugs quickly and safely.